The platform is based around the Nexera ultra high-performance liquid chromatograph. The Nexera Semi-Prep SFC System is part of SSI’s Nexera UC platform, which accommodates a wide variety of analyses and purifications. This next-generation prep SFC system provides the pharmaceutical industry with reliable high-performance semi-prep purification. Ideally would prefer flow at least up to 350 mL/min with at least up to 50% modifier.Shimadzu Scientific Instruments (SSI), in partnership with the Enabling Technologies Consortium™ (ETC), announces the release of the Nexera Preparative Supercritical Fluid Chromatography System. This would be somewhat restrictive and on the lower side for prep scale. Given this flow restriction would you consider this as a Prep Scale system? variables for all editable set points: mobile phase%, flowrate, back pressure, temp, wavelength, cycle time, # injections, collector settings).įLOW RATE – 150-500 mL/min 50% modifier : We can offer a configuration that could deliver 300 mL/min CO2 & 150 mL/min Modifier. REPORTING – Customized Reporting : Our software provides custom reporting, but could you supply an example of the type of reporting that you would like?Ĭustom reports are acceptable. Include run conditions (i.e. METHOD EDITING – Simple, graphical (visual), “on-the-fly” editing: Can you be more specific on which parameters would need to be changed on-the-fly? For example would you want to change the gradient conditions or CO2/Modifier ratio? Could you provide a prioritized list of editable set points?įraction collector settings (time, threshold, slope) Carry Over = not detected on baseline resolved test mix ![]() Low-pressure with visible GLS : Can you clarify what is meant by low pressure? 95% on baseline resolved test mix. Would you want to have multiple columns in the oven? If so how many? Just a clarification, we meant BPR control up to at least 200 bar (and system pressure up to at least 400 bars).ĬOLUMN TEMP – Efficient temperature control to at least 60 degrees C. Did you mean to infer that the pressure be able to change during a run? We assume that you would program a specific pressure to be run during the whole method. PRESSURE – Programmable up to at least 200 bar : Our current BPR is programmable up to 400 bar. However, having the capability to switch between columns (for example two prep columns on the oven) can save time and allow for quick and on-the-fly column switching without having to depressurize the system. The question is whether or not you would want to have the capability for multiple columns to be installed with a selector valve to choose which column to use?Ĭolumn selector valve is not a requirement. TYPICAL COLUMN SIZE – 2-3 cm x 25 cm : This size falls within our current capability, so no issues. RFI ISSUED JRESPONSES DUE AUGQUESTIONS RECEIVED (UPDATED AUGUST 6, 2016) In this project, desired hardware and software requirements and performance criteria collected from a cross-pharmaceutical group of SFC users will be shared with potential instrument providers, in the hope of identifying partners interested in developing, optimizing, and/or commercializing the “next-generation” of preparative SFC instrumentation collaboratively.ĭownload the Request for Information and submit your response. Consequently, pharmaceutical companies interested in the planned replacement of aging instrumentation are uncertain how to proceed. However, these prep SFC instruments have some performance and dependability limitations, and are generally considered to be inferior to the Berger Multigram II, a ‘gold standard’ for small scale prep SFC purification that is no longer manufactured. Since then several vendors have entered and exited the prep SFC marketplace and a number of commercial instruments are currently available. ![]() Preparative SFC has been a preferred method for small scale purification in the pharmaceutical industry for about 15 years, since the prep SFC instrument was introduced by the now defunct Berger Instruments. Next-Generation Preparative Supercritical Fluid Chromatography Instrumentation
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